http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2015073724-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_4efd81a278d7969dcf3d9b07cacd35e4 |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2510-00 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-5011 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-5088 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-50 |
| filingDate | 2014-11-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9e3805df5b256e6cb805e3093526fab0 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_45a2fc8788b926699e726beed795da7b http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2dc626c465d0068ca437a33d54a6de59 |
| publicationDate | 2015-05-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | WO-2015073724-A1 |
| titleOfInvention | 3d cell culture and ex vivo drug testing methods |
| abstract | Provided herein are methods for testing proliferative responses of a drug on patient-derived tumor cells; the method comprising obtaining cells from biopsy or tumor resection material; culturing the cells on a 3D extracellular matrix (ECM); treating the cells in ECM with a drug; subjecting the treated cells to high-content (HC) imaging; and evaluating the HC imaging of the treated cells; thereby testing the proliferative responses of the drug on the patient-derived tumor cells. In some embodiments, the methods disclosed herein comprise obtaining cells from biopsy or tumor resection material; xenografting the cells into an animal model (patient-derived xenograft; PDX) for tumor formation; and obtaining tumor cells from the animal. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2017174609-A1 |
| priorityDate | 2013-11-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 76.