| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_c7fd38ff393036b78f4fa402ddeeae2d |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2506-1353
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2501-11
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2500-84 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-28
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N5-0619
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N5-0622
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N5-0618
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K35-28
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K35-30
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-00 |
| filingDate |
2014-10-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3832bc0e42158f8ed76cb571bd01aa6e
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4496f7c42b8d5bc76e68f57434aafcf2 |
| publicationDate |
2015-04-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
WO-2015056258-A2 |
| titleOfInvention |
Method of obtaining terminally differentiated neuronal lineages and uses thereof |
| abstract |
The present disclosure concerns a method of inducing transdifferentiation of mesenchymal stem cells (MSC), the method comprising (a) culturing MSC in a first culture medium comprising a growth factor selected for allowing formation of neuralized MSC (NMSC); (b) allowing the NMSC to proliferate for a sufficient time during which said culture medium is renewed at least once; and (c) culturing the NMSC of (b) in a second culture media comprising cerebrospinal fluid (CSF) for a time sufficient for the NMSC to differentiate into a population of cells comprising terminally differentiated neurons, astrocytes and oligodendrocytes. Also provided by the present invention is the use of MSC or NMSC for providing a composition comprising said population and to kits comprising MSC or NMSC and instructions for use of same. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2019053729-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11136548-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2016210313-A1 |
| priorityDate |
2013-10-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |