| abstract |
The present invention provides a process for preparing a functionalised cellulose chromatography medium, which process comprises (i) providing one or more non- woven sheets, each comprising one or more cellulose acetate nanofibres, (ii) pressing the one or more non-woven sheets, (iii) heating the one or more non- woven sheets to fuse points of contact between sections of the one or more cellulose acetate nanofibres, (iv) treating the pressed and heated product to convert the cellulose acetate to cellulose, and (v) contacting the thus-obtained product in a batchwise fashion between two and four times with a reagent which functionalises the product of step (iv) as a chromatography medium. The present invention further provides a process for the isolation of biological molecules i a mobile phase with the said functionalised cellulose chromatography medium. |