| abstract |
The present invention provides a production method for a diazabicyclooctane derivative expressed by formula (IV), and an intermediary body thereof (in the formula: P is an acid-removable NH protective group; R 1 represents a 2,5-dioxopyrrolidine-1-yl, a 1,3-dioxo-3a, a 4,7,7a-tetrahydro-1H-isoindole-2(3H)-yl, a 1,3-dioxohexahydro-1H-isoindole-2(3H)-yl, or a 3,5-dioxo-4-azatricyclo[5.2.1.0 2,6 ]deca-8-en-4-yl; R 2 represents hydrogen, C1CO-, or C1 3 COCO-, R 3 represents a C 1-6 alkyl or a heterocyclyl, or joins with a bonded -O-NH- to form a 3-7 member heterocyclyl ring; and OBn represents a benzyloxy). |