| abstract |
Provided are a small interfering nucleic acid against CKIP-1 gene inhibiting bone formation, pharmaceutical composition thereof and uses thereof in preparing pharmaceutical composition for treating and/or preventing diseases related to the abnormal expression of CKIP-1 gene. The small interfering nucleic acid is capable of cross-species inhibiting CKIP-1 gene expression, inhibiting CKIP-1 expression in human, rhesus monkey, rat and mice simultaneously, and facilitating the differentiation of osteoblasts and the mineralization of bone matrix effectively. |