http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2014210031-A9

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filingDate 2014-06-24-04:00^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_93b82a56fd3338778fc4daaa0c07864f
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publicationDate 2015-04-02-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber WO-2014210031-A9
titleOfInvention Proteomic biomarkers of sepsis in elderly patients
abstract A proteomic expression platform to identify age-related sepsis risk is disclosed using patients with community-acquired pneumonia. A semi-quantitative plasma proteomics workflow was applied which incorporated tandem immuno affinity depletion, iTRAQ labeling, strong cation exchange fractionation, and nanoflow-liquid chromatography coupled to high resolution mass spectrometry. A protein profile was determined that exhibit statistically significant differences in expression levels amongst patients with severe sepsis as a function of age. Representative pathways that are differentially-expressed include, but are not limited to, acute phase response, coagulation signaling, atherosclerosis signaling, lipid metabolism, and production of nitric oxide/reactive oxygen species.
isCitedBy http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-109030834-A
priorityDate 2013-06-25-04:00^^<http://www.w3.org/2001/XMLSchema#date>
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