| abstract |
The present invention relates to a chewable tablet comprising granules containing tadalafil or a pharmaceutically acceptable salt thereof as an active ingredient; granules having a specific particle size and density prepared by a wet granulation; at least one disintegrant selected from the group consisting of sodium starch glycolate, carboxymethyl cellulose calcium, starch, alginic acid, and sodium alginate; and a pharmaceutically acceptable additive. The chewable tablet according to the present invention exhibits excellent dissolution rate, causes little foreign body sensation in the oral cavity, and does not cause unpleasant feelings when disintegrated in the oral cavity due to improved taste and flavor. Also, the chewable tablet can be chewed without water to improve compliance rate of patients who do not have difficulty in swallowing. Therefore, the inventive formulation can improve efficacy of PDE-5 inhibitors, and thus can be useful in the treatment of ED and pulmonary arterial hypertension. |