| abstract |
The invention concerns a method for producing granules containing at least one active ingredient and stable at ambient temperature, comprising the successive steps of: (1) preparing a matrix free of active ingredient by mixing, without the addition of water, an encapsulation vehicle for the active ingredient and a non-aqueous plasticiser compatible with said vehicle and with the chosen active ingredient, the encapsulation vehicle and the plasticiser being present in amounts that give the matrix a vitreous transition temperature higher than ambient temperature, (2) heating the matrix in an extruder to an extrusion temperature in order to obtain an amorphous melt matrix, (3) injecting the active ingredient into the melt matrix, in order to provide the melt mass with a given active agent, (4) extruding the melt mass provided with the active ingredient through a die and cutting same into granules at an exit point of this mass from the die. The invention is applicable in the food industry, cosmetics and pharmaceutical fields. |