http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2014198010-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_fa832338299b6ad5ec7886ac979a6bdd |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2310-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01R33-5601 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K49-1857 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K49-1848 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K49-085 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-115 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K49-1851 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K49-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-115 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N24-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-68 |
| filingDate | 2013-10-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_fcf7d6893095a970b459d08b517f9b40 |
| publicationDate | 2014-12-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | WO-2014198010-A1 |
| titleOfInvention | Targeting aptamer for atherosclerosis and preparation method and application thereof |
| abstract | Provided are a targeting aptamer for atherosclerosis and preparation method and application thereof. The targeting aptamer for atherosclerosis is obtained through screening of macrophage-derived foam cells together with the reverse screening of smooth muscle cells, endothelial cells, and THP-1 cells using the SELEX method; and the use of the targeting aptamer in preparation of a target MRI nano-contrast agent for atherosclerosis allows the specific binding of the target MRI nano-contrast agent for atherosclerosis only with the macrophage-derived foam cells, and allows high specific binding thereof in AS diseased vascular tissues, thus improving targeting of the target MRI nano-contrast agent for atherosclerosis and realizing early specific diagnosis of arterial sclerosis. |
| priorityDate | 2013-06-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 83.