| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_1bba710e7aaa56d8ab15a910fcd3dc5f |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Y114-14001
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Y106-02004 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D493-04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12P17-181
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N9-0071
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N9-0042 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-5377
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D493-04 |
| filingDate |
2014-06-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e37f0f982c00e87fd70ab886465d9cb6
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_99a94d2ea999c7c2804b4c40c5143b26
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_528e993df93019e4b1426860e3c54abb |
| publicationDate |
2014-12-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
WO-2014197591-A2 |
| titleOfInvention |
Parthenolide derivatives, methods for their preparation and their use as anticancer agents |
| abstract |
Methods are provided for the generation of parthenolide derivatives functionalized at carbon atoms C9 and C14. Natural cytochrome P450 enzymes, and engineered variants of these enzymes, are used to carry out the hydroxylation of these sites in parthenolide. These P450-catalyzed C-H hydroxylation reactions are coupled to chemical interconversion of the enzymatically introduced hydroxyl group to install a broad range of functionalities at these otherwise unreactive sites of the molecule. The methods can also be used to produce bifunctionalized parthenolide derivatives, which in addition to modifications at the level of carbon atom C9 or C14, are also functionalized at the level of carbon atom C13. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-106366088-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-3407885-A4
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10512630-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10428082-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2018280346-A1 |
| priorityDate |
2013-06-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |