| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_2f70fbcb50a577c8d40360fb9d9c1ad8 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2333-70539
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2333-70514
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2469-10
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K2039-605
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2319-00 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-505
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-56972
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-56977
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-70514
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-70539
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-7051
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K17-14 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K7-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-50 |
| filingDate |
2014-05-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_fc6660afa10fc17490c872180988f1df
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f71a7b78b66e387871e028ccdaecfd34
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_19cd76f762ea39898d251fa7cce0ea7c |
| publicationDate |
2014-12-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
WO-2014191432-A1 |
| titleOfInvention |
Improved method for the detection, preparation and depletion of cd4+ t lymphocytes |
| abstract |
The present invention relates an in vitro method for detecting class II restricted CD4+ T cells in a sample. Herein a sample is contacted with an isolated complex of an MHC class II molecule and a peptide. This peptide comprises an MHC class II restricted T cell epitope of an antigenic protein and immediately adjacent thereof, or separated by a linker of at most 7 amino acids a sequence with a [CST]-xx-C or C-xx-[CST] motif. CD4+ T cells are detected by measuring the binding of the complex with cells in the sample, wherein the binding of the complex to a cell is indicative for the presence of CD4+ T cells in the sample. The present invention further relates to an isolated complex of an MHC Class II molecule and a peptide comprising an MHC class II restricted T cell epitope of an antigenic protein and immediately adjacent thereof, or separated by a linker of at most 7 amino acids a sequence with a [CST]-xx-C or C-xx-[CST] motif. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10729791-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-109069604-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11718650-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2017147139-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11226332-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2020099356-A3
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10662232-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/RU-2761653-C2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2018162498-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10808016-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10899795-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11760782-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11407795-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10617748-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2021028503-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11193114-B2 |
| priorityDate |
2013-05-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |