abstract |
The invention relates to a pharmaceutical dosage form comprising: (i) at least one formed segment (S 1 ), which contains a first pharmacologically active ingredient (A 1 ) and provides prolonged release thereof, and (ii) at least one further segment (S 2 ), which contains a second pharmacologically active ingredient (A 2 ) and provides immediate release thereof, wherein the at least one formed segment (S 1 ) exhibits a higher breaking strength than the at least one further segment (S 2 ) and the at least one formed segment (S 1 ) exhibits a breaking strength of more than 500 N. |