http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2014180271-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_41cfacda69cf945e5eb2d1a004344777 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_d54301cd69ffa711aa99276a8cebdb24 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D405-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D307-20 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D405-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D307-20 |
| filingDate | 2014-04-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c167d6630cce17b679d6ef6213023042 |
| publicationDate | 2014-11-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | WO-2014180271-A1 |
| titleOfInvention | Method for preparing afatinib and intermediate thereof |
| abstract | Revealed in the present invention is a method for preparing Afatinib (I): using 2-nitrile-4-[4-(N,N-dimethylamino)-1-oxo-2-buten-1-yl]amino-5-[(S)- (tetrahydrofuran-3-yl)oxy]aniline (II) and 4-fluoro-3-chloroaniline (III) as starting materials, and respectively performing a condensation and cyclization reaction with N,N-dimethylformamide dimethyl acetal (IV) to prepare Afatinib (I), wherein the method significantly reduces the manufacturing steps of Afatinib and greatly lower the costs. In addition, also provided in the present invention is a method for preparing an intermediate of Afatinib, wherein the method has a stable process, uses readily available starting materials, has a low cost, and all the reactions are classic reactions, suitable for meeting amplification requirements in the industry. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-113004212-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-104478863-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-113024472-A |
| priorityDate | 2013-05-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 55.