http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2014174437-A1

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filingDate 2014-04-22-04:00^^<http://www.w3.org/2001/XMLSchema#date>
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publicationDate 2014-10-30-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber WO-2014174437-A1
titleOfInvention Method for drug loading hydroxyapatite coated implant surfaces
abstract A method for loading a hydroxyapatite coated implant with a therapeutic agent including the steps of providing an implant and applying a hydroxyapatite coating on a surface of the implant. The hydroxyapatite coated implant is contacted with a solution including the therapeutic agent. The hydroxyapatite coated implant and solution is heated to temperature of about 60 ˚C to about 100˚C. Pressure is applied to the hydroxyapatite coated implant and solution from about 2 bar to about 10 bar, to load the hydroxyapatite coated implant with the therapeutic agent. An implant made according to the method has sustained therapeutic agent delivery and includes a base and a biomimetic hydroxyapatite coating disposed on a surface thereof.
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