| abstract |
Provided is a hydrophilic polymer derivative having a benzylidene acetal linker, of which the hydrolysis rate at a pH value of a weakly acidic environment in a living body can be controlled accurately.nA hydrophilic polymer derivative having a benzylidene acetal linker, which is represented by formula (1) (wherein R 1 represents a hydrogen atom or a hydrocarbon group; R 2 , R 3 , R 4 , R 5 and R 6 independently represent a hydrogen atom or a substituent, wherein at least one of R 3 , R 4 and R 5 represents an electron-withdrawing substituent or R 2 and/or R 6 represents a substituent; X 1 represents a chemically reactive functional group; P represents a hydrophilic polymer; w represents an integer of 1 to 8; and Z 1 and Z 2 independently represent a selected bivalent spacer). |