abstract |
Provided in the present invention are a new anti-angiogenic compound and a preparation method and use thereof. The compound of the present invention has a good anti-angiogenic effect, and this compound is initially considered to act by inhibiting VEGFR2 (i.e. KDR), thereby generating activity. Such compounds can be used for the treatment of diseases caused by abnormal protein kinase such as neovascularization, VEGFR2, PDGFR-β, and KIT, for example, wet macular degeneration, malignant tumours etc. |