http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2014153337-A2
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_de094784025e53546f898a3de5a5e393 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_114e4423ec77cbc8dab9d0a98909704e |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D249-06 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4192 |
| filingDate | 2014-03-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2c33c7b6fecf95623f142040a0661a52 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e66652944e9ef0cce741e3aaa38743e5 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7e093d4aed465a79b351327b62541427 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_21632f627fa3db7aeb33cd4696b6ad46 |
| publicationDate | 2014-09-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | WO-2014153337-A2 |
| titleOfInvention | Small molecule inhibitors of pi3-kinase signaling |
| abstract | Provided are certain 1,2,3-triazole and 1,2,3-triazole dimer analogs of DM-PIT-1 which are second-generation selective non-phosphoinositide small molecule inhibitors of phosphatidylinositol-3,4,5-trisphosphate (PIP3), including 1,2,3-triazoles represented by formula (I) where: Ar represents aryl or heteroaryl; X represents O or S; each of R a , R b , R c , and Rd independently represents hydrogen, halogen, C 1 -C 10 alkyl, -OH, -CF 3 , aryl, amino, or nitro; and Ar is optionally substituted with one or more substituents independently selected from the group consisting of halogen, C 1 -Cioalkyl, -OH, -CF 3 , amino, and nitro. Also provided are pharmaceutical compositions comprising compounds of the invention and a pharmaceutical carrier. Also provided are methods of inhibiting PIP3-mediated signaling in a cell and treating cancer using compounds of the invention. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2021005222-A1 |
| priorityDate | 2013-03-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
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