| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_dcce39a20bef16c3f04497659caba40f |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-05
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-6803
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-6849 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-48 |
| filingDate |
2014-03-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_521fa619bc11254f443e4a8f2c86bbbe
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f63a7169327354afdbbe2f2bc4f280a9 |
| publicationDate |
2014-09-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
WO-2014152199-A1 |
| titleOfInvention |
Antibody drug conjugate (adc) purification |
| abstract |
The invention provides methods for obtaining compositions having antibody drug conjugates (ADCs) with specified drug to antibody ratios (DARs). Included in the invention is a method for purifying an ADC mixture having ADCs with a drug loaded species of 6 or more by contacting the mixture with a hydrophobic resin such that a composition comprising less than 15% of the 6 or more drug loaded species is obtained. The invention also provides a composition wherein 70% or more of the ADCs present have a drug loaded species of 4 or less, wherein the ADC comprises an anti-EGFR antibody and an auristatin. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2016515511-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-111529717-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2016144773-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-106999606-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2016131409-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2023012669-A2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-106999606-B
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2021024133-A2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9827330-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10098968-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10792370-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9493568-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11759527-B2 |
| priorityDate |
2013-03-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |