abstract |
Positron-emitting fluoridated organo-fluoroborates comprising at least one 18 F atom and precursors thereto, for use in position-emission tomography (PET) scanning and methods for their production are provided. The compounds have the general formula ( Y 1 ) n ( Y 2 )B( A) (I); wherein B is boron, A is a linear or branched alkyl, alkenyl, alkynyl or non-aromatic cycloalkyl group, any of which may include a heteroatom; A is joined to B through a carbon atom; each Y 1 and Y 2 are selected from the group consisting of a non-interfering group with regard to the fluoridation of B, a 18 F or a 19 F, wherein at least one of ( Y 1 ) n and Y 2 is 18 F; and provided that A is selected such that the pK a of H a of an acid of the formula H a OC(O)A is less than or equal to about 2.8. |