| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_bcff13f8573db698307f919e6385d5c4 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-395
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-428
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-05
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-4439
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D417-14
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D277-64 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D417-14 |
| filingDate |
2014-02-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_518b529856fd83e1f58b4d339ecff3d3 |
| publicationDate |
2014-09-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
WO-2014134243-A1 |
| titleOfInvention |
Pharmaceutical compounds and use of same in cancer and tauopathies |
| abstract |
Disclosed are compounds of formula (l)-(V): where the substituents are as provided herein. Further disclosed are methods of inhibiting tau aggregation, treating or ameliorating a tauopathy or cancer by administration of such a compound. Tau is a microtubule-binding protein that accumulates in a number of neurodegenerative disorders, including frontotemporal dementia and Alzheimer's disease (AD). The presence of abnormal tau correlates with neuron loss and memory deficits in patients with AD and other neurodegenerative disorders that involve tau accumulation. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/KR-20210087490-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2023100942-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11236085-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-3242555-A4
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10899735-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10710986-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10774071-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11555029-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10221171-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2016112394-A1 |
| priorityDate |
2013-02-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |