| abstract |
The present invention relates to a compound or a pharmaceutically acceptable salt or solvate thereof for use in inhibiting HIV capsid assembly, the compound comprising the core structure wherein E is CR 7 or S, and wherein f is 0 or 1, and wherein in case E is S, f is 0, and wherein the core structure is at least substituted in 2 and 4 position, and wherein the residue R6 and R 7 , are, independently of each other, selected from the group consisting of -H, -D, -alkyl, alkoxy, alkenyl, alkynyl, halides, -NO 2 , - OH, -NH 2 , -NHR 4# , -CN, - S(O)R 4# , -SO 2 R 4# , -P(O)R 4# R 5# , -P(O)(OR 4# )R 5# , -P(O)(OR 4# )(OR 5# ), -C(O)NR 4# R 5# , - C(O)SR 4# , -C(O)R 4# , -C(O)O-R 4# , alkoxy and glycol chains; and wherein R 6 may optionally form a cyclic residue, with a further substituent present 5 or 6 position, and wherein R 4# and R 5# are, independently of each other, selected from the group consisting of -H, -alkyl, -alkenyl, -heterocyclo alkyl, aryl and heteroaryl. |