| abstract |
The present invention provides specific sites for modifying antibodies or antibody fragments by replacing at least one amino acid in the constant region of a parental antibody or antibody fragment with a TAG-encoded amino acid such as Pcl, which can be used as a site of attachment for a payload or linker-payload combination. The invention includes modified antibodies or antibody fragments, various conjugates formed therefrom, and uses of the modified antibodies or antibody fragments and their conjugates. |