| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_2a819eda0adf22936a52362eeebb9fb4
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_2f4adec611c2f5a6c9c82830d4cbbcda
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_c25db6eb44cf761cd4d00cff78dae4ed
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_385dc768c1317bc83cbb7a5057a81765 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-166
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-341
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-381
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D307-68
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P37-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D333-38 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D307-40
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-381
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P37-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D333-10 |
| filingDate |
2014-01-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_994b355422a750c115860cf148fd8634
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_839101fe26bdfa3a845fb2b183582b61
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_20c2d415fd4d468887218629103854ef |
| publicationDate |
2014-08-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
WO-2014120790-A1 |
| titleOfInvention |
Small molecules to block signaling pathway |
| abstract |
Methods and compositions of this invention relate to suppressing Ca 2+ -Release-Activated- Ca 2+ (CRAC) channel activity using novel compounds of Formula (I): Compounds of formula (I) have been shown to modulate calcium transport through the CRAC channel. The function of the CRAC channel is important for the immune response and is largely limited to cells of the immune system. Accordingly, in one aspect, there is provided a method for suppressing immunity in a mammal in need thereof comprising administering a compound of Formula (I) in an amount sufficient to inhibit CRAC channel activity. Also provided are pharmaceutical compositions and kits comprising compounds of formula (I). |
| priorityDate |
2013-01-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |