http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2014094462-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_d51c6eeb6bd2590571d3f68c2273be11 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12P17-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12P17-00 |
| filingDate | 2013-09-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f5474745484441c47e97703d86be7678 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a0b316b2056e4f5407df1c29ef7b094b |
| publicationDate | 2014-06-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | WO-2014094462-A1 |
| titleOfInvention | Biological preparation method of (s)-3-methylamino-1-(2-thienyl)-1-propyl alcohol |
| abstract | The present invention provides a biological preparation method of (S)-3-methylamino-1-(2-thienyl)-1-propyl alcohol, wherein 3-methylamino-1-(2-thienyl)-1-acetone is used as a substrate; under a condition that a biocatalyst ketoreductase, a cofactor and a cofactor regeneration system (comprising glucose and glucose dehydrogenase) exist, the substrate undergoes an asymmetric reduction reaction to generate the (S)-3-methylamino-1-(2-thienyl)-1-propyl alcohol; the asymmetric reduction reaction is carried out in a water-phase buffer solution with a pH of 6-8; and in a initial reaction system, concentration of the substrate is 100-150 mg/mL, and a mass ratio of the ketoreductase to the substrate is 1-2%. The present invention improves the concentration of the substrate and reduces enzyme usage. |
| priorityDate | 2012-12-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 20.