http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2014090128-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_cd8085afa10af0b1dcb892c6378adb8d |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C08B37-0012 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-61 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C08B37-0015 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-365 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-366 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-48 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C08B37-16 |
| filingDate | 2013-12-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3c4ac21c63b6f598fdf9088771db9074 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_47c017a20a5834f6ed1e356ed767db18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_07a44b040cec584ed64e6cdf59596581 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_89703ffe6de65ca10340b612382b47fb http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0137c22a1a9227484fa2d1d84b3d7c3f http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ea6de65a7377d2d6abbd4265df9a33e3 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_815ba299047054681743cf825fba710f |
| publicationDate | 2014-06-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | WO-2014090128-A1 |
| titleOfInvention | Arteannuin cyclodextrin conjugate and preparing method thereof |
| abstract | Disclosed are an arteannuin cyclodextrin conjugate and a preparing method thereof. The present invention relates to the field of pharmaceutical synthesis. The arteannuin cyclodextrin conjugate in the present invention uses cyclodextrin as a carrier, and molecules of an arteannuin compound are connected by using an amido bond formed between a carboxyl group of the molecules of the arteannuin compound and an amido group of the cyclodextrin modified by the amido group. Compared with arteannuin and dihydroartemisinin, the arteannuin cyclodextrin conjugate in the present invention has more hydrophilic active groups, and has good biocompatibility, better water solubility and high bioavailability. In another aspect, the arteannuin cyclodextrin conjugate in the present invention has anticancer target feature, and specifically for colorectal cancer cells, the arteannuin cyclodextrin conjugate can effectively enter the body of a patient, gather around target cancer cells at a top priority, and selectively induce rectum cancer cells of a human body to die, thereby improving pharmacodynamic effects and reducing toxic or side effects. The method for preparing the arteannuin cyclodextrin conjugate in the present invention features simple operations, easy availability of materials and moderate reaction conditions, and can be used for manufacturing a great amount of the arteannuin cyclodextrin conjugate. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-112111025-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-112111025-B http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2017226851-A |
| priorityDate | 2012-12-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 114.