| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_7bce595c861dba361078ba893e4713be |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2800-04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2800-044
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2333-4745
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2333-47 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K7-06
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-6893 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-53
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-68
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-48 |
| filingDate |
2013-12-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_469123695c726af62aeb98f22fb33ecf |
| publicationDate |
2014-06-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
WO-2014089262-A1 |
| titleOfInvention |
Diagnosis and therapy of chronic inflammation-induced disorders |
| abstract |
Methods and compositions for the diagnosis and treatment of chronic inflammation (obesity)-induced disorders such as insulin resistance, diabetes, cancer and various metabolic disorders, are provided. The methods and compositions detect both full-blown disease and early stage disease by detecting proteolysis, by neutrophil proteases, of insulin-like growth factor binding protein-3 (IGFBP3). Levels of proteolytic fragments of IGFBP3 and/or levels of intact IGFPB-3 and/or levels/activity neutrophil proteases are detected. Agents (e.g. peptide agents) that inhibit the proteolysis of IGFPB-3 and methods of using the agents to prevent and treat chronic inflammation (obesity)-induced disorders are also provided. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2022086347-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10682391-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2017117236-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11020453-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2016193497-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2016193496-A1 |
| priorityDate |
2012-12-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |