| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_e54bf8bf8371150bc6e6fece65fef083
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_0617046a31a89931467a2d31425ccd1e
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_1efbf0a2167bf797d1f39bcfa9b5f0ec |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2840-007
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K2217-203
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K2267-01
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K2217-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K2227-10
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2830-008
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2999-007
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2800-30 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-8771
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61D19-04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K67-0275
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-8778
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K67-0273 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A01K67-027 |
| filingDate |
2013-11-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c287249bc40845d99a28bda7637e5c78
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_149fcc3118e57e8fa811517f88018481
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_73179a7b9a7103fc85837eb257438f13 |
| publicationDate |
2014-06-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
WO-2014085501-A1 |
| titleOfInvention |
Cloned non-human animals free of selective markers |
| abstract |
Genetically modified somatic cells of a non-human animal are provided that are engineered to contain a self-excisable, recombinase expression cassette comprising a site- specific recombinase gene operably linked to an ES cell-specific promoter. Compositions and methods for producing a genetically modified, cloned non-human animal that is free of a selective marker gene and a recombinase gene are provided, wherein a targeting construct comprising a self-excisable recombinase gene operably linked to an ES cell-specific promoter is introduced into differentiated somatic cells. The genetically modified genome of the somatic cells is transferred into an enucleated host oocyte. The artificially created zygote is then cultured in vitro until the blastocyst embryonic stage and subsequently implanted into a uterus of a surrogate mother to form a genetically modified, cloned non-human animal free of selective marker and recombinase genes. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-105200086-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11246299-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2016140353-A1 |
| priorityDate |
2012-11-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |