| abstract |
The present invention relates to the field of the chemical medicines, and in particular, to a compound with a Heteroaryl alkyne structure shown in formula I or pharmaceutically acceptable salts, isomers, solvate, crystal or prodrug thereof, pharmaceutical compositions containing there compounds and applications of these compounds or compositions in the medicine preparation. The compound of the present invention has a strong inhibiting effect on BCR-ABL kinase, and can be used for treating, for example, neoplastic diseases. |