http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2014079801-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_6590cdd11c644b30c2159cdee5e707c6 |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07J31-006 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P11-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-1688 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N15-0211 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-008 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-0073 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-56 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-569 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07J31-00 |
| filingDate | 2013-11-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6daafe1f904db7bc176aae68e3e15bf4 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_cfae7f153d7e8a4516975c372ed0d34b |
| publicationDate | 2014-05-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | WO-2014079801-A1 |
| titleOfInvention | Method for increasing the particle size of crystalline active micro-particles |
| abstract | The invention relates to a method for increasing the particle size of crystalline active micro-particles comprising the following steps: (a) a first suspension consisting of crystalline active micro-particles with a first d 50 value of 0.5-5 μm, solvent for the active agent and anti-solvent for the active agent is provided, wherein the solubility of the active agent in the solvent/anti-solvent mixture of the first suspension is 0.001-0.5% by weight; (b) the first suspension is stirred; (c) the d50 value of the active micro-particles contained in the first suspension is determined at least once, wherein a second d50 value is obtained; (d) the first suspension is stirred further; (e) the first suspension is filtered off, wherein a filter cake is produced, which is washed with anti-solvent for the active agent, wherein a differential pressure of ≤ 500 mbar is present between the top and bottom of the filter cake during the filtering-off process and the filter cake is dehumidified to not below 80% by weight of the anti-solvent, relative to the total mass of the filter cake, the filter cake obtained then being suspended in anti-solvent, wherein a second suspension is obtained and the d50 value of the active micro-particles of the second suspension is determined, wherein a third d50 value is obtained, wherein the total stirring time of the first suspension is selected so as to be between 1 and 72 hours, depending on the second d50 value, and/or by adding solvent and/or anti-solvent, the solubility of the active agent in the solvent/anti-solvent mixture of the first suspension is altered so as to be between 0.001 and 0.5% by weight such that the third d50 value is at least 0.03 µm greater than the first d50 value; and (f) the active micro-particles of the second suspension are then dried. Moreover, crystalline fluticasone propionate particles are provided, the mean particle size being d50 = 1-1.5 μm, the span being ≤ 1.35 and the amorphous fraction relative to the total weight of the particles is ≤ 0.5% by weight. |
| priorityDate | 2012-11-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
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