| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_cb8f3eba86915d967beefc175437273a |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2333-723
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2310-14
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q2600-136
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q2600-106
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q2600-156
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q2600-158
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-76 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K16-2857
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-4439
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-1138
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-70567
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K49-0008
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q1-6886
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-5011
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-4166 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-68 |
| filingDate |
2013-10-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ecf537ed9d48c41d0502d8c2664a43d4
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b3723628b97aa883217bff0594f1963b
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5cd86ca77170ccc291dac1881e8b2545 |
| publicationDate |
2014-05-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
WO-2014066864-A2 |
| titleOfInvention |
Androgen receptor variants and methods for making and using |
| abstract |
The present invention encompasses the recognition that reproducible and detectable changes in the Androgen Receptor (AR) polypeptide sequence are associated with incidence and/or risk of castration resistant prostate cancer (CRPC), specifically in individuals having prostate cancer and on antiandrogen therapy. The present invention provides novel AR polypeptide sequences associated with increased incidence and/or risk of CRPC. The present invention also provides for identification and/or characterization of novel AR polypeptide sequences associated with increased incidence and/or risk of CRPC via exposure to antiandrogens. The present invention also provides for identification and/or characterization of agents to treat and/or reduce risk of CRPC by virtue of their effect on AR transcriptional activation. The present invention also provides systems for using such agents, for example to treat and/or reduce risk of CRPC. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10527624-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2015179404-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10011874-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-2959013-A2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10981926-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11340228-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10545151-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10000502-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11345956-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2015212089-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10501469-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10613089-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10774387-B2 |
| priorityDate |
2012-10-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |