| abstract |
The present invention provides a compound having the structure: (Formula (I)) wherein X is a therapeutic agent containing at least one amine nitogen and the amine nitrogen on the therapeutic agent covalently bonds directly to carbon α; Z is CH 3 or CF 3 ; R 1 is -H, -NR 2 R 3 , -NH-C (=0) -R 4 , -NH-C (=0) -0R 4 , -CH 2 -C (=0) -NR 5 R 6 , -OR 7 , -CO 2 R 7 , C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, aryl, or heteroaryl, wherein R 2 , R 3 , R 4 , R 5 , R 6 and R 7 are each, independently, -H, C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, heteroalkyl, cycloalkyl, heterocyclyl, aryl, alkylaryl, heteroaryl, alkylheteroaryl, an amino acid or an oligopeptide; wherein an amine of the amino acid or oligopeptide is substituted or unsubstituted; and n is an integer from 0 to 6; or a diastereomer, enantiomer or pharmaceutically acceptable salt of the compound. |