| abstract |
The invention provides a novel sulfonamide compound useful as a drug having a TRPM8-blocking effect. Specifically, the invention provides a sulfonamide compound represented by formula (I) or a pharmaceutically acceptable salt thereof. (In the formula, ring A is formula (i), (ii), or (ix), R 4 is an optionally substituted alkyl, X 1 and X 2 are each independently tetrazolyl, tetrazolinonyl, optionally substituted triazolyl, triazolinonyl, oxadiazolonyl, optionally substituted alkanoylaminomethyl, or optionally substituted alkylsulfonylaminomethyl, or R 4 and X 2 bond to each other at the ends and form indazolinonyl or benzoisoxazolonyl with the adjacent benzene; other symbols are as stated in the specification.) |