| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_ec0024795f45a646ef64b3664ab8a26d
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_3d51a3bbd3fa1ddc931c4f18ecd02cb9 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2710-10332 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K48-005
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-86
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K35-761 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-86
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K35-761
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K35-76 |
| filingDate |
2013-09-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_53636c79086d577cdba20d06e6813328
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_263fb80df8b221e7a33f4f545101ff3a
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6574f32e2fa96cab41f4b1578e590ae0
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5cc7cec91702c3d1bda6897d5d5b5b63 |
| publicationDate |
2014-03-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
WO-2014041119-A1 |
| titleOfInvention |
Oncolytic viruses expressing immuno-nucleases |
| abstract |
The present invention relates to an oncolytic virus comprising an expressible genetic construct encoding a fusion polypeptide, wherein said fusion polypeptide comprises a polypeptide binding to a tumor related cell and a polypeptide having a cytotoxic nuclease activity, and to said oncolytic virus for use as a medicament and for the treatment of cancer. The present invention further relates to a method of killing tumor related cells comprising contacting said tumor related cells with the oncolytic virus of the present invention, incubating said tumor related cells under conditions allowing expression of said expressible genetic construct, and thereby killing said tumor related cells. Further, the present invention relates to the use of the oncolytic virus of the invention for the treatment of cancer and for killing cancer cells, as well as to kits and devices comprising said oncolytic virus. |
| priorityDate |
2012-09-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |