| abstract |
Disclosed is a pharmaceutical composition for inhibiting autophagy of motor neurons containing an effective amount of an active ingredient. The active ingredient is selected from the following groups: a compound of formula (I), pharmaceutically acceptable salts thereof, pharmaceutically acceptable esters thereof and a combination of the foregoing, wherein A is C 1 -C 5 hydrocarbyl with one or more unsaturated bond as needed and is substituted by one or more substituent selected from the following groups as needed: -OΗ, =O, and C 1 -C 3 hydrocarbyl; X is Η, -OΗ, formula (II) or formula (III); Y is O or S, and can form a five-membered ring by binding with A as needed; and R 1 is H or a substituted or unsubstituted C 1 -C 20 hydrocarbyl, wherein one or more -CH 2 - of the hydrocarbyl is replaced by -NH- or -O- as needed. |