http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2014023952-A2
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_d4260a256b5f28ea7d92b4c1f5b921d0 |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2800-105 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K67-0275 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-6869 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K39-395 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-20 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A01K67-027 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-68 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K16-00 |
| filingDate | 2013-08-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_09ece10f384d521c3cbf2f5aeae1edbb http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9674f0fa6ec607d8fd003e05eb9fd493 |
| publicationDate | 2014-02-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | WO-2014023952-A2 |
| titleOfInvention | Prevention and treatment of osteoarthritis |
| abstract | There is provided an interleukin-18 (IL-18) inhibitor for use in the prevention or treatment of injury-induce dosteoarthritis in a joint of a subject. Also provided is a method for treating or preventing injury-induced osteoarthritis in a joint of a subject, comprising administering to the subject an effective amount of an interleukin-18 (IL- 8) inhibitor. Also provided is an in vitro method for diagnosing or predicting the risk of acute injury osteoarthritis in a joint of a subject, said method comprising (i)10 determining the amount of IL-18 in a sample from said subject;(ii)comparing the amount of IL-18 in the sample with a reference standard; and(iii)identifying a difference in the amount of IL-18 biomarker in the sample relative to the reference standard;wherein an increase in the amount of IL-18 in the sample compared to the reference standard correlates with the presence of, or an increased risk of, injury-1 induced osteoarthritis; and a decrease, or no change, in the amount of IL-18 in the sample compared to the reference standard correlates with the absence of, or a lack of increased risk of, injury-induced osteoarthritis. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11298327-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2016073326-A3 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-4173622-A4 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10772846-B2 |
| priorityDate | 2012-08-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 160.