| abstract |
The present invention provides a dabigatran etexilate derivative shown as a formula (I), or pharmaceutically acceptable salt, a solvate, a polymorph, an antipode, or a racemic mixture thereof. In the formula (I), R 1 is hydrogen or C 1 to C 5 alkyl, R 2 is a formula (II), R 3 and R 4 are independently hydrogen or C 1 to C 5 alkyl, n is 0 or 1, and R 5 is C 1 to C 8 alkyl or optionally substituted C 1 to C 8 alkyl. The compound has the activity of a thrombin inhibitor. The present invention also provides a preparation method for the compound, a compound-containing medical composition, and application of the compound and the medicinal composition to preparation of thrombin inhibitor medicines and treatment of related diseases. |