http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2013188600-A1

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filingDate 2013-06-12-04:00^^<http://www.w3.org/2001/XMLSchema#date>
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publicationDate 2013-12-19-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber WO-2013188600-A1
titleOfInvention Copy number aberration driven endocrine response gene signature
abstract Disclosed are methods of predicting the likelihood of long-term survival without recurrence of breast cancer for a subject having estrogen receptor-positive (ER+) breast cancer treated with adjuvant endocrine monotherapy. In various embodiments, these methods comprise performing a gene expression profile of a breast tissue sample of substantially all of the genes of the "CADER set" described herein; calculating a risk score using a regression model; and applying a double median cutoff classification to assign the subject to a sensitive, indeterminate or resistant group, wherein assignment to a sensitive group predicts longer relapse-free survival compared to the median relapse-free survival of ER+ breast cancer patients treated with adjuvant endocrine monotherapy.
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