| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_576b9046efb9f2ab883f80ed8280ba9c |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61B6-037 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-5005
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K49-0032
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61B6-032
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K51-0472
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61B5-0035
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61B5-0059
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K51-044
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K51-08
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K49-0002
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K49-0043
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61M5-007 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K49-06
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K49-10
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K51-04 |
| filingDate |
2013-06-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b061f09c45e56a581e38da936d1a5ae6
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_897bae0fb7a3f4c322622edd78832079
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a672fa517d525aeac990f539fcf3a09f |
| publicationDate |
2013-12-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
WO-2013184678-A1 |
| titleOfInvention |
Molecular probes for multimodality imaging of anionic membrane surfaces |
| abstract |
Embodiments provide dual modality probes for imaging phosphatidylserine (PS) exposure and other anionic membrane surfaces. In various embodiments, the probes were constructed by utilizing a) the high selectivity of synthetic zinc (II) dipicolylamine coordination complexes (Zn-DPA) for targeting externalized PS which over-expresses in apoptotic and necrotic cells, b) a near-infrared (NIR) dye for optical imaging, and c) a widely used clinically approved radionuclide for PET (or SPECT) imaging. A variety of linking elements were incorporated into the probes between the Zn-DPA and radionuclide motif to modulate the pharmacokinetics. The in vitro and in vivo data of radiolabeled dipicolylamine probes demonstrated their utilities for imaging PS exposure with multiple imaging modalities. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/AU-2015264409-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-110101876-A |
| priorityDate |
2012-06-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |