| abstract |
The present invention relates to compounds that can be used link substrates to molecules, typically for biological applications such as imaging and the like. The compounds contain a cyclooctyne which is joined, via a linking group, to a moiety such as a squarate, amine, aminooxy, hydrazide, semicarbazide or carbohydrazide. The cyclooctyne moiety acts as the coupling partner to an azide-functionalised substrate or molecule, whilst the other moiety acts as the coupling partner to an amine-, aldehyde- or ketone-functionalised molecule or substrate. The invention therefore also relates to processes of synthesis of such compounds and further use of the compounds to link a substrate to a molecule. |