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filingDate 2013-05-16-04:00^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f6719157809f2d9c46611cbbe5adc5ee
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publicationDate 2013-11-28-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber WO-2013175103-A1
titleOfInvention Method for attenuating a bacterium of the mycobacterium tuberculosis complex for producing a tuberculosis vaccine
abstract The present invention relates to the use of a strain of a mycobacterium of the Mycobacterium tuberculosis complex, into which an mspA gene capable of expressing a Mycobacterium smegmatis porin A has been inserted, for producing a vaccine for the prevention of an infection by a bacterium of the Mycobacterium tuberculosis complex in a host comprising eukaryotic cells, preferably macrophages, wherein said mycobacterial strain thus transformed exhibits reduced growth in said eukaryotic cells.
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