| abstract |
The present invention describes the method for producing the dichloromethane fraction and subfractions of Eleutherine plicata , commonly known as "marupazinho, maruparí, palmeirinha, coquinho, marupaí, marupaú, marupá-piranga, lírio-folha-de-palmeira". The invention further includes the preparation of pharmaceutical compositions that contain the dichloromethane fraction and/or naphthoquinone, as well as the use thereof for the treatment of malaria. The extract and fractions described were tested and showed antiplasmodium activity, in particular against chloroquine-resistant Plasmodium falciparum (W2). |