| abstract |
Disclosed in the present invention is a pharmaceutical composition, comprising a weight ratio of 1 : 120 to 1 : 1000 of Camptothecin compounds of formula I and β-cyclodextrin or derivatives thereof, and an acidic buffer to adjust the pH = 3.5-6.0. The composition can be used to treat solid tumours, such as melanoma, pancreatic cancer, liver cancer, etc. The pharmaceutical composition of the present invention is miscible with a water-miscible co-solvent system in any proportion, and can be used as an intravenous infusion solvent, and has no obvious hemolysis or vascular stimulation; the pharmaceutical composition has a better tumour inhibiting rate than solubilization of surfactants. |