| abstract |
Compounds of the invention are useful in inhibiting thrombin and associated thrombotic occlusions having the following structure: (I) or a pharmaceutically acceptable salt thereof, wherein Q is CH 2 , NR 4 , O, S, S(O) or S(O 2 ), wherein R 4 is H, C 1-6 alkyl, aryl, or C 3-8 cycloalkyl; R 1 is a heterocycle or -(CR 5 R 6 )1-2NH2, wherein R 5 and R 6 , each time in which they occur, are independently H, C 1-6 alkyl, -CH 2 F,-CHF 2 , CF 3 or -CH 2 OH; R 2 is OH, NH 2 or NHSO 2 CH 3 ; and R 3 is C 1-6 alkyl. |