| abstract |
The purpose of the present application is to provide an orally disintegrating tablet having excellent tablet hardness and disintegrating performance, a disintegrating particulate composition by which the orally disintegrating tablet is obtained with relatively low tablet compression force and which is able to impart excellent moldability, a method for producing the same, and the like. The present application pertains to: a method for producing a disintegrating particulate composition including the three components of a first disintegrating tablet component comprising acid-type carboxymethylcellulose, a second disintegrating tablet component, and an excipient, wherein the method includes a first wet granulation step for using any two components of the three components, and a second wet granulation step for using the granulated material obtained in the first wet granulation step and the remaining one component of the three components; a production method further including crystalline cellulose as a fourth component; a production method comprising a third step for mixing crystalline cellulose into the granulated material obtained in the second wet granulation step; disintegrating particulate compositions obtained by these production methods; and the like. |