http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2013127829-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_8c606898d4aa4e50a6c01258ac129ce6 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_9d12b35c0dd9adfb167b3b4f383afe93 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K49-1866 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K7-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K39-39533 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K49-0093 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K49-0056 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-198 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-64 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-62 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K7-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-48 |
| filingDate | 2013-02-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4e5f98eb60104d3be602f722c815f270 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7efa37f8fc02cad3c772d9f1650e76cd http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6a3d56a664eeafcbab76627968347ba3 |
| publicationDate | 2013-09-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | WO-2013127829-A1 |
| titleOfInvention | Protease-resistant compounds useful as shuttles through the blood-brain barrier and shuttle-cargo constructs |
| abstract | The peptides of formula (I) R 1 -(X) K -P-Y, where: R 1 is the group attached to the N-terminal of the first amino acid of the sequence P, optionally via the ligand X, and is selected from H, CH 3 C(=O)-, and maleimide;X is a biradical selected from-NH-(CH 2 ) r- C(=O)-, -C(=O)-(CH 2 ) r -C(=O)-, -S(CH 2 ) r -, -S-(CH 2 ) r -C(=O)-, -O-(CH 2 ) r -, -S-CH 2 -CH(NH 2 )-C(=O)-, –O-(CH 2 ) r -C(=O)-, -(CH 2 ) r -C(=O)-, -NH-O-CH 2 -C(=O)-NH-(CH 2 ) r -CH(NH 2 )-C(=O)-, -(CH 2 ) r -C(=O)-NH-(CH 2 ) r -CH(NH 2 )-C(=O)-, and –NH-(CH 2 ) r -CH(NHC(=O)CH 2 NH 2 )-C(=O)-; r is 1-5; P is a biradical of an amino acid sequence comprising the sequence D-Pro-D-Trp- D-Val-D-Pro-D-Ser-D-Trp-D-Met-D-Pro-D-Pro-D-Arg-D-His-D-Thr (SEQ ID NO: 1); Y is the group attached to the C-terminal of the last amino acid of the sequence P, and is selected from -NH 2 , -OH, -OR 2 and -NHR 2 ; R 2 is a radical selected from (C 1 -C 6 )-alkyl and (CH 2 ) 2 -NH-C(=O)-CH 2 -O-NH 2 ; k is 0-2; m is 0-1; with the proviso that when the biradical X is –C(=O)(CH 2 ) r C(=O)-, then R 1 is H; when the N of the amino acid of the sequence P to which is attached the biradical X is a biradical -NH-, then m is 1, and when is a biradical -N-, then m is 0; and when R 1 is maleimide then the biradical X is -C(=O)-(CH 2 ) r -C(=O)-,-CH(NH 2 )-C(=O)-, -(CH 2 ) r -C(=O)-, and -(CH 2 ) r -C(=O)-NH-(CH 2 ) r -CH(NH 2 )-C(=O)-. The peptides are useful as shuttles through the blood brain barrier (BBB). The constructions BBB-shuttle-cargo, being the cargo of a biologically active substance or for use in a diagnostic method, are useful in therapy and diagnosis. |
| priorityDate | 2012-02-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 122.