| abstract |
A novel solid form of bosentan comprises as the active ingredient the N-[6-(2- Hydroxyethoxy)-5-(2-methoxyphenoxy)-2-pyrimidin-2-yl-pyrimidin-4-yl]-4-tert-butyl- benzenesulfonamide] and maleic acidor gentisic acid, especially as cocrystal former. The composition shows improved properties such as dissolution kinetic and hydration stability. |