| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_c5c2d6a5a07914730d77e365aec0bf14 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K2039-542 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Y301-06004
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N9-16
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K39-001 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-10
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K39-00 |
| filingDate |
2013-02-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c789ef235c93520c29482a9d619c3e22
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f4282065e6924e0cca9a4f3eba289d0b
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5cce9e66ca30b0b0a08e217037a60f32
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_92287d1237764f994564e0b4e8c7f6ac
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_08551fd98ed36467cf3e30be4048841c
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_fc7c092992a87816a449399ddf4bfa3c |
| publicationDate |
2013-08-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
WO-2013119715-A1 |
| titleOfInvention |
Determination of immunogenic peptides in lysosomal enzymes and induction of oral tolerance |
| abstract |
Disclosed are methods and compositions for determining immunodominant peptides of target enzymes used in enzyme replacement therapy for lysosomal storage disorders. More specifically disclosed are immunodominant peptides for N-acetyIgalactosamine-6-suifatase (GALNS). Also disclosed are methods of inducing oral tolerance towards a target enzyme through oral administration of immunodominant peptides prior to commencing enzyme replacement therapy. More specifically disclosed is a method of inducing oral tolerance for GALNS, by orally administering specific immunodominant peptides for GALNS; in subjects suffering from mucopolysaccharidosis type IVA prior to commencing enzyme replacement therapy using GALNS. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10801018-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10472615-B2 |
| priorityDate |
2012-02-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |