| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_18fcfe210bcd989eea02e71597c183f0
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_956ce22957c939ed9ce29827ddfcf45e
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_ac316c4307d2a84add2bae0328f607bd |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2799-025
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K48-005 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N9-1205
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q1-6869
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-10
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Y207-01002 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-867
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P3-10
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N9-12
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K48-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-45 |
| filingDate |
2012-02-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7709e3b0487584decd7a408b5ab1c0a7 |
| publicationDate |
2013-08-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
WO-2013117776-A1 |
| titleOfInvention |
Glucokinase enzymes with increased activity and use thereof in the treatment and/or prevention of diabetes mellitus |
| abstract |
The present invention relates to coding nucleotide sequences for mutated glucokinase enzymes that have greater enzymatic activity, to genetic constructions that include same, to the amino acid sequences coded by same, to pancreatic islets that express same and to the uses thereof for the treatment and/or prevention of diabetes mellitus. The pancreatic islets that express the amino acid sequences corresponding to the glucokinase enzyme variants described in the invention are highly effective, since they include pancreatic β-cells which have greater capacity for proliferation and induce a reduction in the insulin release threshold in response to glucose. In addition, said types of islets are larger than the pancreatic islets from control individuals, and are therefore useful in cell-therapy treatment of diabetes mellitus. |
| priorityDate |
2012-02-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |