| abstract |
The present invention relates to the reversal of senescence, in particular the reversal of p16-mediated replicative senescence, using p16 inhibitors. The p16 inhibitors are generally small interfering RNA (siRNA) molecules that target and silence p16 expression, or anti-micro RNA molecules that target and disrupt senescence-associated micro RNA molecules. The use of such inhibitors in ex vivo cell culture methods, treatment of age-related disorders, cell culture media, reperfusion solutions, anti-ageing compositions, anti-wrinkle compositions and wound healing promoting compositions are also provided. |