Predicate |
Object |
assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_44f04d319aaa6e66f240244bc905f452 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_22d9dcb36b7cd5c71c931f1d8a22e3b1 |
classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K35-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2319-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2830-003 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2800-22 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2710-10343 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2710-10043 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K35-28 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K35-50 |
classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-525 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K35-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Y207-01021 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K48-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K48-005 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-86 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-861 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-11 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N9-1211 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-191 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N7-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 |
classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K35-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-861 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N7-01 |
filingDate |
2013-02-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9d8a3b7bf777d7e1770a443b77d5dad9 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f83bf76ae1b88445bf8341cfb371ad9b http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f0584c1118aee5610d2ee622465948e5 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_699a1526b79040c21ea6d3bd22981328 |
publicationDate |
2013-08-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
publicationNumber |
WO-2013115608-A1 |
titleOfInvention |
Vector simultaneously expressing dodecameric trail and hsv-tk suicide genes, and anticancer stem cell therapeutic agent using same |
abstract |
The present invention relates to: a DNA cassette comprising a nucleic acid sequence coding for dodecameric TRAIL and a suicide gene nucleic acid sequence; a recombinant expression vector comprising the DNA cassette; a recombinant adenovirus made using the recombinant expression vector; a host cell transfected by means of the recombinant adenovirus; a composition for treating cancer comprising the host cell; and a cancer treatment method comprising a step of administering the composition for treating cancer to an individual. A stem cell therapeutic agent, with which dodecameric TRAIL and HSV-TK are simultaneously produced by introducing the DNA cassette of the present invention, has superior anticancer effects to those of existing therapeutic agents, and thus can effectively be used in the treatment of various solid cancers and metastatic cancers. |
priorityDate |
2012-02-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
type |
http://data.epo.org/linked-data/def/patent/Publication |